May 24 2017 : The Times of India (Chennai)
Study reveals how neem can cure oral cancer
Bosco Dominique
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Cuddalore
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India's traditional toothbrush, the neem, has properties that can prevent oral cancer, scientists from the biochemistry and biotechnology department at Annamalai University in Chidambaram have confirmed.While neem's anti-cancer properties have been demonstrated several times by a number of researchers, scientists in Annamalai University demonstrated that a bioactive ingredient, nimbolide, activates a tumour suppressor protein called RECK (Reversion-inducing Cysteinerich Protein with Kazal Motifs), which is found in all normal tissues but is low or absent in malignant tumours. The research, they hope, will enable the manufacture of drugs that improve survival rates and treatment outcomes in patients with oral cancer.
The research study , pub lished in a peer reviewed journal, Scientific Reports, Nature Publication Group in May , said nimbolide, derived from the leaves and flowers of the neem tree, could be used effectively to treat oral cancer, said biochemistry and biotechnology professor Siddavaram Nagini. In the laboratory , a team of researchers showed that nimbolide prevents cancer progression by preventing growth of uncontrolled malignant cells. It also spreads to other tissues through new blood vessels and kills cancer cells.
“RECK has tumour suppressing properties. In normal cells, it maintains tissue architecture and prevents infiltration and spread of tumour cells to other organs. In cancer, an array of molecules inhibits the function of RECK. Nimbolide suppresses the functions of the molecules that inhibit the function of RECK,“ Nagini said.
The team is planning to conduct large-scale studies to analyse the therapeutic potential of nimbolide as a stand-alone drug and in combination with other chemotherapeutic drugs in other preclinical cancer models.They also have proposed to study the absorption, distribution, metabolism, and excretion properties of nimbolide. They have established the anticancer properties of neem extracts and neem compounds, especially nimbolide, through a series of studies over the past two decades.
The research study , pub lished in a peer reviewed journal, Scientific Reports, Nature Publication Group in May , said nimbolide, derived from the leaves and flowers of the neem tree, could be used effectively to treat oral cancer, said biochemistry and biotechnology professor Siddavaram Nagini. In the laboratory , a team of researchers showed that nimbolide prevents cancer progression by preventing growth of uncontrolled malignant cells. It also spreads to other tissues through new blood vessels and kills cancer cells.
“RECK has tumour suppressing properties. In normal cells, it maintains tissue architecture and prevents infiltration and spread of tumour cells to other organs. In cancer, an array of molecules inhibits the function of RECK. Nimbolide suppresses the functions of the molecules that inhibit the function of RECK,“ Nagini said.
The team is planning to conduct large-scale studies to analyse the therapeutic potential of nimbolide as a stand-alone drug and in combination with other chemotherapeutic drugs in other preclinical cancer models.They also have proposed to study the absorption, distribution, metabolism, and excretion properties of nimbolide. They have established the anticancer properties of neem extracts and neem compounds, especially nimbolide, through a series of studies over the past two decades.
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